This looks worth checking out:

Gridless

“an awesome HTML5 and CSS3 framework for making responsive, cross-browser websites with beautiful typography”

Most responsive and adaptive HTML/CSS frameworks or boilerplates start with desktop styles and use media queries to serve mobile browsers the right layout. The problem is that most mobiles won’t respond to these media queries because they don’t support it. Also, using a polyfill like Respond.js will not give you any result because they are very limited devices and don’t even support JavaScript.

But Gridless uses a different approach: it uses media queries to serve a progressively-enhanced responsive layout, starting from mobile and building up to desktop sizes.

via Gridless – An awesome boilerplate for responsive, cross-browser websites.